Vowels have low point values, so I would prioritize getting new tiles. It might be different if you could somehow play six or seven of these tiles, but I think 4 vowels left is still more than the optimal number.

You’re not showing the rest of the board, so of the letters visible, ‘oi’ on the beginning of oozed is the best I see.

“Aeon” or “iota” would be much better, if there’s a cooperative n or t.

Neighborhood defense crabs, yes.